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This handbook provides entry points for policy makers for how to shift food systems towards providing safer, affordable, accessible, and nutritious diets. The handbook includes sections on evidence, recommendations, and examples, focusing on 13 key topic areas: food price volatility, climate change, food safety, healthy meals in schools, food environments, consumer behavior, metrics and data, bio fortification, food loss and waste, cost of malnutrition, private sector, urbanization, and sustainable development goals. Policy makers could draw from and adapt ideas outlined in this handbook to develop policies tailored to their specific context.