Climate change is a global crisis, but its effects are not equal. As temperatures and sea levels rise, the effects disproportionately impact the poorest and most marginalized communities USAID works to support every day. In response to these global challenges, USAID launched a Climate Strategy that will guide its work through 2030. This new Strategy takes a “whole-of-Agency” approach that calls on all corners of USAID to play a part in the response. Every USAID sector and Mission has a role to play in transforming global systems, including building resilience of food and health systems to respond to humanitarian crises and other disruptive impacts of climate change.