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Red blood cell production and associated biological systems are complex. In addition to iron, other micronutrients are essential for the function of a healthy blood system and thus, play a role in the prevention of anemia. The body must maintain red blood cell production to replace cells lost through natural removal of aged or damaged cells from circulation or to offset bleeding. The lifespan of normal red blood cells is approximately 120 days; the body requires sufficient amounts of key nutrients to support the replacement of red blood cells at a rate of 1 percent daily.

From a research perspective, we need to further understand and quantify the nature of the interactions of multiple micronutrients (iron, vitamin A, riboflavin, vitamin B12 or folate) to improve nutritional assessment and interventions in the context of anemia. Vitamin A deficiency leads to anemia that is not corrected by administration of iron. This is because vitamin A deficiency causes a reduction in iron absorption or utilization, and only the concurrent administration of vitamin A with iron will alleviate the anemia. In addition, vitamin A deficiency is associated with reduced immune response and predispose deficiency individuals to increased infections, which in turn can induce anemia.

We found 4 resource(s)

Accelerating Action to Reduce Anemia: Review of Causes and Risk Factors and Related Data Needs
Literature Review published by Ann N Y Acad Sci in
This narrative review describes the causes and risk factors, and related data needs for reducing anemia for different population subgroups within a country and presents principles for the design and implementation of effective strategies to prevent and treat anemia.
Anemia Epidemiology, Pathophysiology, and Etiology in Low- and Middle-Income Countries
Journal Article published by Ann N Y Acad Sci in
This review outline definitions and classifications of anemia, describe the biological mechanisms through which anemia develops, and reviews the variety of conditions that contribute to anemia development.
Six Key Actions to Reduce Anemia
Toolkit published by SPRING in
This brief describes country-led efforts to coordinate and implement anemia prevention and control, offering lessons learned to help other countries design the best possible solutions.
Impact of Folate Supplementation on the Efficacy of Sulfadoxine/Pyrimethamine in Preventing Malaria in Pregnancy: The Potential of 5-methyl-tetrahydrofolate
Literature Review published by Journal of Antimicrobial Chemotherapy in
This review synthesizes evidence on malaria folate metabolism and antifolate efficacy in the context of folate supplementation. Findings indicate 1) that there is a dose-dependent effect of folate supplementation on antifolate efficacy and that folic acid doses required for protecting pregnant women from neural tube defects will not decrease…