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Iron and micronutrients supplementation has been used widely to correct specific nutritional deficiencies linked to anemia. Oral iron supplements are the first-line treatment for iron deficiency and iron deficiency anemia in women of reproductive age. Gastrointestinal side effects from iron supplement intake are commonly reported, but can be decreased by following proper dosing regimens. Iron preparations available on the market vary widely in dosage, formulation, cost, and bioavailability.

Highly bioavailable ferrous iron is generally the most effective formulation for replenishing hemoglobin in patients with iron-deficiency anemia. However, the most commonly used formulation is the least expensive form, ferrous sulfate, which is more likely than ferrous iron to cause gastrointestinal discomfort. The bioavailability of another formulation, ferric iron is 3 to 4 times lower than that of ferrous sulfate. In areas with a high burden of viral, parasitic, and/or bacterial infections, aiming supplementation at children who are anemic or at risk of iron deficiency is suggested, accompanied by malaria prevention and disease treatment strategies. Vitamin A supplementation can improve hemoglobin concentrations.

We found 61 resource(s)

Ferric Carboxymaltose Versus Standard-of-Care Oral Iron to Treat Second-Trimester Anaemia in Malawian Pregnant Women: A Randomised Controlled Trial
Journal Article published by Lancet in
This paper presents the results of an open-label, individually randomized controlled trial of a single dose of a modern intravenous iron formulation, ferric carboxymaltose, for anaemia treatment in pregnant women in Malawi with a singleton pregnancy of 13–26 weeks' gestation in primary care and outpatient settings.
Effects of Iron Supplementation on Neural Indices of Habituation in Bangladeshi Children
Journal Article published by Am J Clin Nutr in
This paper reports on the effect of iron supplementation on neural indices of habituation using auditory event-related brain potentials within a three-arm, double-blind, double-dummy, individual randomized trial in Bangladesh, in which 3,300 eight-month-old children were randomly selected to receive three months of daily iron syrup (12.5 mg iron…
Supplementation With Iron Syrup or Iron-Containing Multiple Micronutrient Powders Alters Resting Brain Activity in Bangladeshi Children
Journal Article published by Journal of Nutrition in
This study reports on the results of supplementation with iron or multiple micronutrient powders (MNPs) on brain activity measures using resting electroencephalography within a three-arm, double-blind, double-dummy, individual randomized trial in Bangladesh, in which 3,300 eight-month-old children were randomly selected to receive three months of…
Iron, Folic Acid, and Multiple Micronutrient Supplementation Strategies during Pregnancy and Adverse Birth Outcomes in Botswana
Journal Article published by The Lancet Global Health in
Researchers tested four supplementation strategies and found that women who used multiple micronutrient supplementation had lower risk of preterm and very preterm births and low and very low birthweight when compared with other supplementation protocols.
Antenatal Multiple Micronutrient Supplements Versus Iron-Folic Acid Supplements and Birth Outcomes: Analysis by Gestational Age Assessment Method
Journal Article published by Maternal & Child Nutrition in
Trials performing ultrasounds for gestational age assessment found benefits of multiple micronutrient supplements (MMS) on low birthweight, preterm birth, and small for gestational age. These analyses strengthen the evidence for the transition from iron-folic acid supplements to MMS in antenatal care programs.
The Effect of Interventions Distributing Home Fortification Products on Infant and Young Child Feeding (IYCF) Practices: A Systematic Narrative Review
Literature Review published by Maternal & Child Nutrition in
This narrative review describes the effect of interventions distributing home fortification products like micronutrient powders and small-quantity lipid-based nutrient supplements on infant and young child feeding practices.
The Effect of Oral Iron Supplementation on Gut Microbial Composition: A Secondary Analysis of a Double-Blind, Randomized Controlled Trial Among Cambodian Women of Reproductive Age
Journal Article published by Microbiol Spectr in
This study is a secondary analysis of a double-blind, randomized controled trial of oral iron supplementation in Cambodian women of reproductive age, which examined the effects of two oral iron supplements of differing bioavailability—ferrous sulfate or ferrous bisglycinate- or placebo on the gut microbiome.
The Effects of Oral Ferrous Bisglycinate Supplementation on Hemoglobin and Ferritin Concentrations in Adults and Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Systematic Review published by Nutrition Reviews in
This systematic review of randomized controled trials evaluates the effects of ferrous bisglycinate supplementation compared with other iron supplements on hemoglobin and ferritin concentrations, and gastrointestinal adverse events, among pregnant women and children.